Friday, September 16, 2016

SFX 200 DT Cefixime Dispersible Tablet

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Brand Name -- SFX 200DT

Treatment ---

.›   Urinary and gynecologic infections including gonorrhea. 
›   Respiratory tract infections. 
›   Otitis media. 

Contraindicated in: 

•   Hypersensitivity to cephalosporins. 
•   Serious hypersensitivity to penicillins. 
Use Cautiously in: 
•   Renal impairment ( dosing/ dosing interval recommended if CCr 60 mL/min). 
•   History of GI disease, especially colitis. 

Adv. Reactions/Side Effects 

CNS: seizures (very high doses).
GI: pseudomembranous colitis, diarrhea, nausea, vomiting, cramps.
Derm: rashes, urticaria.
Hemat: bleeding, blood dyscrasias, hemolytic anemia.
Misc: allergic reactions including anaphylaxis and serum sickness, superinfection.


•   PO (Adults and Children >12 yr or >50 kg): Most infections — 400 mg once daily.Gonorrhea — 400 mg single dose. 
•   PO (Children): 8 mg/kg once daily or 4 mg/kg every 12 hr . 

Renal Impairment

•   PO (Adults): CCr 21–60 mL/min — 75% of standard dose; CCr 20ml/min — 50% of standard dose. 


•   Similar to that of second-generation cephalosporins, but activity against staphylococci is less, while activity against gram-negative pathogens is greater, even for organisms resistant to first- and second-generation agents. 
•   Notable is increased action against. ›   Enterobacter. 
›   Haemophilus influenzae. 
›   Escherichia coli. 
›   Klebsiella pneumoniae. 
›   Neisseria. 
›   Proteus. 
›   Providencia. 
›   Serratia. 
›   Moraxella catarrhalis. 
›   Borrelia burgdorferi. 

 Pregnancy Category 
Category B

Therapeutic Classification: anti-infectives

Pharmacologic Classification: third generation cephalosporins
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