Brand Name -- SFX 200DT
Treatment ---
.› Urinary and gynecologic infections including gonorrhea.
› Respiratory tract infections.
› Otitis media.
Contraindicated in:
• Hypersensitivity to cephalosporins.
• Serious hypersensitivity to penicillins.
Use Cautiously in:
• Renal impairment ( dosing/ dosing interval recommended if CCr 60 mL/min).
• History of GI disease, especially colitis.
Adv. Reactions/Side Effects
CNS: seizures (very high doses).
GI: pseudomembranous colitis, diarrhea, nausea, vomiting, cramps.
Derm: rashes, urticaria.
Hemat: bleeding, blood dyscrasias, hemolytic anemia.
Misc: allergic reactions including anaphylaxis and serum sickness, superinfection.
Route/Dosage
• PO (Adults and Children >12 yr or >50 kg): Most infections — 400 mg once daily.Gonorrhea — 400 mg single dose.
• PO (Children): 8 mg/kg once daily or 4 mg/kg every 12 hr .
Renal Impairment
• PO (Adults): CCr 21–60 mL/min — 75% of standard dose; CCr 20ml/min — 50% of standard dose.
Spectrum:
• Similar to that of second-generation cephalosporins, but activity against staphylococci is less, while activity against gram-negative pathogens is greater, even for organisms resistant to first- and second-generation agents.
• Notable is increased action against. › Enterobacter.
› Haemophilus influenzae.
› Escherichia coli.
› Klebsiella pneumoniae.
› Neisseria.
› Proteus.
› Providencia.
› Serratia.
› Moraxella catarrhalis.
› Borrelia burgdorferi.
Pregnancy Category
Category B
Therapeutic Classification: anti-infectives
Pharmacologic Classification: third generation cephalosporins
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